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D 2,000 IU D3 Ultra K2-D3

Ultra K2-D3 provides the recommended amount of vitamins K2 and a liberal amount of vitamin D3, the preferred form of vitamin D. These vitamins are specific for calcium metabolism, bone health and density retention. Research has recently shown the majority of North Americans are deficient in these vitamins, especially during dark winter months, and thought to be directly responsible for a portion of adult bone breakage. As a pleasant tasting, chewable tablet, Ultra K2-D3 is easily taken by people who find it difficult to swallow supplements and need vitamins K2 and D3.



Research

  Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Alt Med Rev. 2008;13(1):6-20.
  This is an extremely useful review article on vitamin D. The multiple conditions that may develop due to vitamin D deficiency are described. Supplementation amounts for all age groups and special populations are outlined.
  Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87(suppl):1080S-86S.
  Dr. Holick is a noted authority on vitamin D and is lead author in this excellent review on vitamin D deficiency.
  Ngo DT et al. Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations? Am J Med. 2010;123:335-41.
  C-reactive protein is a general marker of systemic inflammation, while endothelial nitric oxide reduces hypertension and promotes vasorelaxation. The study found that low 25-hydroxyvitamin D3 concentrations are associated with increases in both high-sensitivity C-reactive protein and asymmetric dimethylarginine that inhibits endothelial nitric oxide.
  Hathcock JN et al. Risk assessment for vitamin D. Am J Clin Nutr. 2007;85:6-18.
  The purpose of this review article is to identify the appropriate upper limit for vitamin intake, which typically applies to supplemental levels as the food supply naturally contains little vitamin D. The authors identify 10,000 IU as the tolerable upper limit, which amounts to 250 mcg.
  Holick MF. Vitamin D deficiency: what a pain it is. Mayo Clin Proc. 2003;78:1457-59.
  An excellent review of how vitamin D deficiency can promote musculoskeletal pain.
  Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463-70.
  The prevalence of hypovitaminosis D was unexpectedly high in this population of nonelderly, nonhousebound, primary care outpatients with persistent, nonspecific musculoskeletal pain refractory to standard pharmaceutical agents. Of all patients, 93% (140/150) had deficient levels of vitamin D (mean, 12.08 ng/mL). Normal level is 32-100 ng/mL.
  Schwalfenberg G. Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series. J Am Board Fam Med. 2009;22:69-74.
  This article reviews 6 selected cases of improvement/resolution of chronic back pain or failed back surgery after vitamin D repletion in a Canadian family practice setting. Vitamin D insufficiency is common; repletion of vitamin D to normal levels in patients who have chronic low back pain or have had failed back surgery may improve quality of life or, in some cases, result in complete resolution of symptoms.
  Cannell JJ. Vitamin D Council Newsletter. March, 2007. Vitamin D and athletic performance.
  Dr. Cannell reviews numerous articles that span from 1938-2007 on the topic of vitamin D and athletic performance. http://www.vitamindcouncil.org/
  Cannell JJ. Epidemic influenza and vitamin D. Epidemiol Infect. 2006;134:1129-40.
  This article focuses on the importance of vitamin D and immune function. Emerging research demonstrates that vitamin D deficiency can promote viral and bacterial infections.
  Gombart AF. The vitamin D-antimicrobial peptide pathway and its role in protection against infect. Future Microbiology. 2009;4(9):1151-65.
  This article focuses on the importance of vitamin D and immune function. Emerging research demonstrates that vitamin D deficiency can promote viral and bacterial infections.
  Urashima M et al. Randomized trial of vitamin D supplementation to prevent seasonal in?uenza A in schoolchildren. Am J Clin Nutr. First published ahead of print March 10, 2010 as doi: 10.3945/ajcn.2009.29094.
  This article focuses on the importance of vitamin D and immune function. Emerging research demonstrates that vitamin D deficiency can promote viral and bacterial infections.
  McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr. 2009;90(4):889-907.
  This is an excellent review article on vitamin K and the proteins it activates. Health implications of a deficiency are described.
  Cranenburg EC et al. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost. 2007;98:120-25.
  The current vitamin K recommendations are appropriate for the carboxylation of clotting proteins, but not for osteocalcin and matrix Gla protein, which are needed for bone and vascular health. This is an excellent review article on this subject.
  Schurgers LJ et al. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arterioscler Thromb Vasc Biol. 2005;25:1629-33.
  In this study, the researchers demonstrated that low circulating matrix Gla protein and impaired gamma-carboxylation of the protein at its tissue site of expression are associated with the development and progression of cardiovascular disease.
  Schurgers LJ et al. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008;100:593-603.
  This is an excellent review article about the relationship between vitamin K and vascular calcification. The authors conclusion: Accumulating data suggest that a high vitamin K2 intake may be an effective interventional strategy to decrease the calcification risk in the general population.
About Us
Founded in 1924, Anabolic Laboratories is a pharmaceutical manufacturer of clinically dispensed nutritional products for the licensed health care professional.

Our manufacturing facilities are located
in Colorado Springs, Colorado &
Irvine, California.
 
Quality Standards
As a United States
federally regulated and
inspected pharmaceutical
manufacturer, our quality
control, manufacturing,
and quality assurance
requirements are the
most stringent in the
world.
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Pain & Inflammation
Chronic inflammation is
recognized as a root cause of
“modern” disease. Causing
pain, fatigue, cognitive
decline, and depression,
chronic inflammation
has reached epidemic
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