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CoQ10

Research has demonstrated that CoQ10 levels are depleted with aging. At least 100 mg per day is estimated to replete CoQ10 levels. CoQ10 is involved in numerous vital metabolic activities including ATP synthesis, free radical reduction, blood sugar regulation, and skeletal muscle gene expression. Multiple capsule sizes and potencies available in easy-to-swallow softgel capsules or regular capsules.



Research

  Crane FL. Biochemical functions of Coenzyme Q10. J Am Coll Nutr. 2001;20(6):591-98.
  In 1957, the author of this paper, Dr. Crane discovered a quinone in mitochondia, which was later to be called ubiquinone (CoQ10). This paper is a review of the basic biochemical functions of CoQ10, such as in energy production and antioxidant metabolism. Aging is associated with a reduction of CoQ10 levels. Normal blood level is about 1 mcg/mL and supplementation with 100 mg/day will elevate to about 2 mcg.mL or more. We normally make CoQ10 and derive very little from diet.
  Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Phys. 2005;72:1065-70.
  A basic review of CoQ10 actions (ATP & antioxidant) followed by a review of the literature regarding supplemental CoQ10 for various conditions. Outcomes are typically modest as most chronic conditions are diverse in nature and the purpose of CoQ10 supplementation is to support normal cell function and metabolism.
  Monograph. Coenzyme Q10. Alt Med Rev. 2007;12(2):159-68.
  A basic review of CoQ10 actions (ATP & antioxidant) followed by a review of the literature regarding supplemental CoQ10 for various conditions. Outcomes are typically modest as most chronic conditions are diverse in nature and the purpose of CoQ10 supplementation is to support normal cell function and metabolism.
  Shults CW et al. Effects of Coenzyme Q10 in early Parkinson disease. Arch Neurol. 2002;59:1541-50.
  A study involving CoQ10 supplementation patients with Parkinson’s disease. The supplemented group had a slower progression of disease versus the placebo group.
  Young AJ et al. Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr. 2007;12(1):62-68.
  A review of the topic of supplemental CoQ10 for neuroprotection.
  Spindler M et al. Coenzyme Q10 effects in neurodegenerative disease. Neuropsych Dis Treat. 2009;5:597-610.
  A review of the topic of supplemental CoQ10 for neuroprotection.
  Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann NY Acad Sci. 2008;1147:395-412.
  This article discusses improving mitochondrial function for neuroprotection and considers CoQ10.
  Qu J et al. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009;50:1814-18.
  CoQ10 levels in the retina can decline by approximately 40% with age. This decline may have two consequences: a decrease in antioxidant ability and a decrease in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progression of macular degeneration, which is the leading cause of blindness in people over the age of 55.
  Hodgson JM et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002;56:1137-42.
  An article examining CoQ10 supplementation in type 2 diabetic patients which describes a modest anti-hypertensive effect of supplementation.
  Chew GT, Watts GF. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the ‘recoupling hypothesis.’ Q J Med. 2004;97:537-48.
  An article examining CoQ10 supplementation in type 2 diabetic patients which describes an anti-endothelialopathy effect.
  Hamilton SJ et al. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009;32:810-12.
  An article examining CoQ10 supplementation in type 2 diabetic patients which describes an anti-endothelialopathy effect.
  Boles RG et al. Treatment of cyclic vomiting syndrome with coenzyme Q10 and amitryptyline, a retrospective study. BMC Neurology. 2010, 10:10
  Compared to placebo, CoQ10 supplementation has been shown to be effective in reducing the frequency of migraine headaches. The outcome of this survey suggests that cyclic vomiting syndrome, which is related to migraine headache and mitochondrial dysfunction, can be reduced with CoQ10 supplementation.
About Us
Founded in 1924, Anabolic Laboratories is a pharmaceutical manufacturer of clinically dispensed nutritional products for the licensed health care professional.

Our manufacturing facilities are located
in Colorado Springs, Colorado &
Irvine, California.
 
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