New Products  New Products Cognagen DeFlame Nutrition Pack Lunora Probiotic 20 Plus Red Yeast Rice Ubiquinol Prime

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Pain & Inflammation  Pain & Inflammation DeFlame Nutrition Pack Disc Support - Nutra Disc® Pro-Enz™ Zymain Salizain™ Pain Recovery Pack® Clinical Magnesium

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Multi-Vitamins  Multi-Vitamins AVED-EZE Multi Vitamin AVED-Multi Softgel AVED-Multi ® AVED-Multi ® Iron Free AVED-Kids Multivitamin Essential Nutrition Pack AVED-Prenatal Multivitamin PMS Multivitamin

Antioxidants  Antioxidants Acetyl L-Carnitine ALA - Vital ALA 300 mg Clinical Antioxidant Complex Biomax C CoQ10 E 400 I.U. Pycnogenol® T.R.I.-C-500 Ubiquinol Prime

Women’s Health  Women’s Health Prenatal Multi - AVED Prenatal Cran-Max Cranberry Iodine from Kelp (Natural Iodine) Iron Chelate Menopause Support Formula Osteo-Plex ® PMS Multivitamin T.R.I.-IRON Complex

Cardio Health  Cardio Health CoQ10 Ubiquinol Prime Garlic High Allicin Niacin Hex (No Flush) Policosanol Microtabs Red Yeast Rice

Children’s Health  Children’s Health Kids Chewable Cee Kids Chewable Multi - AVED-Kids Kids Chewable Omega-3 Pearls

Focused Formulations  Focused Formulations B12-Plus Cal-M Chromease™ Koratate Milk Thistle MSM Neuro-Ease® Prostana Saw Palmetto T.R.I. - Adrenopan T.R.I.- B-Plex Val Rest Vasotate Vitamin A 10,000 IU Zinotate

Enzymes & Digestion  Enzymes & Digestion Digest-A-Mint Digestive Complete Multi-Enzyme Probiotic Complete Fiber (Clinical Fiber) Tabs Probiotic 20 Plus

Immune Support  Immune Support L-Lysine Thymunose Ultra Seasonal Protector Zinc Lozenge, Orange

Aminos, Proteins & Essential Fats  Aminos, Proteins & Essential Fats Complete Omega Complex™ Clinical Omega-3 Flax Seed Oil Kids Chewable Omega-3 Pearls L-Glutamine

Pillows  Pillows Lumbar Cushion

Supports  Supports Neck-Cervical Collars Back-Softex Dual Adjustable Back-Permatex Dual-Adjustable Back-Universal Trochanter Belt Back-Preventative Back Support Back-Power Lifter 5000 Industrial Elbow-Terra-Prene™ Strap Wrist-Elastic Wrist Strap

Product Information & Patient Materials

Coenzyme Q10 200mg Label

Coenzyme Q10 100mg Label

Coenzyme Q10 60mg Label

How Can You Benefit from CoQ10?

Research

Crane FL. Biochemical functions of Coenzyme Q10. J Am Coll Nutr. 2001;20(6):591-98.   In 1957, the author of this paper, Dr. Crane discovered a quinone in mitochondia, which was later to be called ubiquinone (CoQ10). This paper is a review of the basic biochemical functions of CoQ10, such as in energy production and antioxidant metabolism. Aging is associated with a reduction of CoQ10 levels. Normal blood level is about 1 mcg/mL and supplementation with 100 mg/day will elevate to about 2 mcg.mL or more. We normally make CoQ10 and derive very little from diet.

Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Phys. 2005;72:1065-70.   A basic review of CoQ10 actions (ATP & antioxidant) followed by a review of the literature regarding supplemental CoQ10 for various conditions. Outcomes are typically modest as most chronic conditions are diverse in nature and the purpose of CoQ10 supplementation is to support normal cell function and metabolism.

Monograph. Coenzyme Q10. Alt Med Rev. 2007;12(2):159-68.   A basic review of CoQ10 actions (ATP & antioxidant) followed by a review of the literature regarding supplemental CoQ10 for various conditions. Outcomes are typically modest as most chronic conditions are diverse in nature and the purpose of CoQ10 supplementation is to support normal cell function and metabolism.

Shults CW et al. Effects of Coenzyme Q10 in early Parkinson disease. Arch Neurol. 2002;59:1541-50.   A study involving CoQ10 supplementation patients with Parkinson’s disease. The supplemented group had a slower progression of disease versus the placebo group.

Young AJ et al. Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr. 2007;12(1):62-68.   A review of the topic of supplemental CoQ10 for neuroprotection.

Spindler M et al. Coenzyme Q10 effects in neurodegenerative disease. Neuropsych Dis Treat. 2009;5:597-610.   A review of the topic of supplemental CoQ10 for neuroprotection.

Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann NY Acad Sci. 2008;1147:395-412.   This article discusses improving mitochondrial function for neuroprotection and considers CoQ10.

Qu J et al. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009;50:1814-18.   CoQ10 levels in the retina can decline by approximately 40% with age. This decline may have two consequences: a decrease in antioxidant ability and a decrease in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progression of macular degeneration, which is the leading cause of blindness in people over the age of 55.

Hodgson JM et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002;56:1137-42.   An article examining CoQ10 supplementation in type 2 diabetic patients which describes a modest anti-hypertensive effect of supplementation.

Chew GT, Watts GF. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the ‘recoupling hypothesis.’ Q J Med. 2004;97:537-48.   An article examining CoQ10 supplementation in type 2 diabetic patients which describes an anti-endothelialopathy effect.

Hamilton SJ et al. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009;32:810-12.   An article examining CoQ10 supplementation in type 2 diabetic patients which describes an anti-endothelialopathy effect.

Boles RG et al. Treatment of cyclic vomiting syndrome with coenzyme Q10 and amitryptyline, a retrospective study. BMC Neurology. 2010, 10:10   Compared to placebo, CoQ10 supplementation has been shown to be effective in reducing the frequency of migraine headaches. The outcome of this survey suggests that cyclic vomiting syndrome, which is related to migraine headache and mitochondrial dysfunction, can be reduced with CoQ10 supplementation.