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Magnesium - Clinical Magnesium

Magnesium is chronically deficient in the modern diet and promotes a chronic inflammatory state. Magnesium deficiency is associated with diverse clinical manifestations including negative outcomes related to cardiovascular health.  Some researchers have recommended that magnesium be added to the water supply because deficiency is associated with a wide variety of negative health issues. Magnesium plays a crucial role in: glucose metabolism, cellular energy production (ATP), calcium transport, nerve signal conduction, and over 300 enzymatic reactions, some of which are involved in the maintenance of joint and bone health.

Clinical Magnesium includes three organic sources of magnesium for optimal digestion: amino acid chelate, citrate and malate.


  Ford ES, Mokdad AH. Dietary magnesium intake in a national sample of US adults. J Nutr. 2003;133:2879-82.
  This study assessed the intake of magnesium among White, Black, and Hispanic men and women in America. It was determined that all groups consume less than the RDA for magnesium. Health implications are listed by the authors.
  Killilea DW, Maier JA. A connection between magnesium deficiency and aging: new insights from cellular studies. Mag Res. 2008;21(2):77-82.
  Based on epidemiological, cellular, and molecular evidences, the authors propose that broadly correcting the nutritional intake of magnesium might be a simple and inexpensive solution that contributes to healthier aging and the prevention of age-related diseases.
  Liebscher DH et al. About the misdiagnosis of magnesium deficiency. J Am Coll Nutr. 2004;23(6):730S-31S.
  The authors state that the following may be consequences of the magnesium deficiency syndrome: patients with diagnoses of depression, epilepsy, diabetes mellitus, tremor, Parkinsonism, arrhythmias, circulatory disturbances (stroke, cardiac infarction, arteriosclerosis), hypertension, migraine, cluster headache, cramps, neuro-vegetative disorders, abdominal pain, osteoporosis, asthma, stress dependent disorders, tinnitus, ataxia, confusion, preeclampsia, and weakness.
  Begon S et al. Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency. Brit J Pharmacol. 2001;134:1227-36.
  After 9 days of a magnesium deficient diet, rats developed a hyperexcitable nociceptive system, due to the activation of spinal NMDA receptors. No studies on magnesium and pain have been done with humans.
  King DE et al. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005;24(3):166-71.
  Several animal studies have linked magnesium deficiency to increased levels of circulating inflammatory mediators. King et al. demonstrated that low dietary magnesium intake was associated with elevated levels of C-reactive protein.
  King DE et al. Magnesium supplement intake and C-reactive protein levels in adults. Nutr Res. 2006;26:193-96.
  In this study, King et al. demonstrated that those taking magnesium supplements had lower levels of C-reactive protein.
  Senni K et al. Magnesium and connective tissue. Mag Res. 2003;16(1):70-74.
  Magnesium is required for all aspects of connective tissue metabolism and should be a high-priority nutrient for most patients with musculoskeletal complaints.
  Meisel P et al. Magnesium deficiency is associated with periodontal disease. J Dent Res. 2005;84(10):937-41.
  Periodontitis is an inflammatory disease within gingival tissue that appears to be promoted, in part, by an inadequate intake of magnesium. It is suggested that magnesium supplementation could prevent tooth loss in the middle-aged and delay tooth loss in the elderly.
  Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Repro Med. 1990;35(5):503-07. [Abstract]
  The authors present evidence suggesting that magnesium supplementation should be as important, if not more important than calcium, for bone health.
  Dimai HP et al. Daily oral magnesium supplementation suppresses bone turnover in younger adult males. J Clin Endocrinol Metab. 1998;83:2742-48.
  Adequate Mg intake may be equally as effective as adequate calcium intake in promoting achievement of peak bone mass, and so we should not overlook the importance of adequate Mg intake in growing children and young adults. Daily oral Mg supplementation may be used to suppress bone turnover, which subsequently may lead to reduce bone loss and, thus, may have a potential utility for treatment of osteopenia and/or osteoporosis associated with high bone turnover.
  Dominguez LJ et al. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr. 2006;84:419-26.
  Adequate magnesium intake is required for supporting healthy muscle function throughout the life cycle. This may be especially important for those who exercise regularly as magnesium is required for cellular energy production.
  Rayssiguier Y et al. High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation. Mag Res. 2006;19(4):237-43.
  In animal models, magnesium deficiency combined with a high fructose diet induces insulin resistance, hypertension, dyslipidemia, endothelial activation and prothrombic changes in combination with the upregulation of markers of inflammation and oxidative stress. High fructose (high fructose corn syrup) intake and magnesium deficiency are common in the typical Western diet and likely have similar detrimental metabolic effects.
  Lima M et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998;21(5):682-86.
  This study demonstrates the importance of magnesium supplementation for improving glucose control, particularly in those with magnesium deficiency.
  Rodriguez-Moran M et al. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetes subjects. Diabetes Care. 2003;26:1147-52.
  This study demonstrates the importance of magnesium supplementation for improving glucose control, particularly in those with magnesium deficiency.
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